Online:
http://www.netvibes.com  (Clean slick interface, I use it as my home page)

Offline:
http://www.onfolio.com  (Great for organization, research)

Does anyone else thing Google Reader blows UI wise?  The Ajaxian swiftness of it is neat, but I read over 300 feeds, and man it just is a mess to try to navigate. (and I am a big fan of Gmail)