I've been running a SCSI RAID 10 on an Adaptec PCI card under Win2K for about 5 years. I've lost two different Seagate SCSI drives, but the hot spare always worked, and I've never lost any data.

Of course, the e-mail notification never worked...  I had to see the light on the array for one, and the other via a pop-up message when I logged onto the server remotely...