I hope this catches on with photographers.

I would like to convert my 70Mb TIFF files into something more manageable, say 10-20Mb, retaining 16bits per channel.

What it needs is a move from Microsoft or Adobe. Adobe could have native support in Photoshop etc., Microsoft could make it the default format for some Windows/Office applications.

At the moment I can't even find a plug-in for Photoshop CS5.