W3bbo said:
Of course.
Partitioning was a big thing in the 1990s due to the 2GB partition size limit, then with FAT32 it went away. With modern laptops not having optical drives we see the resurgence of partitions for storing recovery data that should remain hidden from the user.
Anyway, spreading files over partitions does not help performance.
we see the resurgence of partitions for storing recovery
What do you mean, resurgence? Every single laptop I've owned since the late 90s has had this, regardless of whether they also included CDs or not. It's hardly a resurgence if it never went away. 
Personally, I still use at least two partitions: one for the OS and applications, and one for data. This is a habit I started when I first joined the Windows 2000 beta program, because it allows me to wipe and reinstall the OS without having to think about
whether I have all my data. I never put anything that's not easily recoverable from some other source on the system partitions, so I always know it's safe to format that partition.
I also don't like combing drives into one partition so I currently have several drive letters for my three separate physical drives. This is more because I fear if one of them fails I'd lose the data on the others too. If you do want to combine them, and
it's performance you're after, I say go the whole nine yards and use RAID 0. 
Unlike with FAT, NTFS cluster size does not grow with partition size. There may be some performance impact from the growth in size of the MFT, but it's minimal. You should however keep the number of files in a single directory low, NTFS does get slow if
that number gets too big.
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