@Ray7: I can't say I've noticed any issues. I've been doing development and all of my normal stuff, both work and personal.
Store apps are in their own silo, and have no effect on the desktop, so my desktop workflow is the same as it's always been. My desktop applications still work the same. There are different API for things, but only if I'm writing Store apps. For other projects I can still access all of the previous APIs and development scenarios in exactly the same way.
Maybe I need more caffeine, but I can't seem to get agitated over anything.