i am hoping someone can help with this odd problem. i just installed a new load of TMG 2010 and everything looks like it is working. got a call from a user that the VPN wasnt working. i started up a VPN and was able to get in. he told me he was wireless so i unplugged and tried to VPN over wifi. my system locked up and i could not connect to any resources. i have to disable the wireless card or reboot to get the system to work correctly. the edge systems are windows 7 and the TMG is server 2008 R2. does the same thing for wifi and cel card conenctions.
Try asking over on isaserver.org - there are a lot of people there with real-life experience in this stuff.