What do you mean? The 1991 remake is the only one that I'm familiar with, and that's not exactly modern anymore.
I've never been a huge fan of LSL, to be honest. It was fun, but not top of my list. The news about the Two Guys and Jane Jensen however, that's what's really got me excited. Gabriel Knight are some of the best games I've ever played.
I do love Mass Effect, but it would've been better if it had been an adventure game. Shooters just aren't my thing, and never will be.