@JoshRoss: I got myself a large Wacom Intuos, for CAD work, and that was a big mistake. The sensor is outstanding, but the working position is kind of awkward, as I like to keep the tablet right in front of me. This leaves no room for the keyboard which I cannot do without (that probably depends on the programs you use, but most seem to have plenty of shortcuts).

I also have lots of problems in doing without a mouse as I find absolute positioning quite tiring. All in all, unless I need pressure sensitivity, I find it's rarely worth the trouble.

Of course, this is quite subjective and the model you mentioned seems to have some nifty features (the multitouch support might solve the mouse issue, at the very least). If you cannot try one out in advance, I would suggest that at least you see if you can find a comfortable working position or you risk finding yourself with a fancy mousepad.