What about a new XBox?
XBox Mobile (Sony Vita)?
This would be insanely cool, a mobile phone capable of playing current XBox games.
HD Kinect? Enough for precision Finger joint recognition and facial expression recognition
Imagine a shoot-em-up where your guns are your hands.
For accessibility imagine someone using Skype where their signing is automatic "translated" into text / speech. And the other callers speech is translate into text / signing.