@lensman: Any CPU is the target.  It debugs when launching from Visual Studio as well as if the EXE is launched and then attached to in Visual Studio.

Uninstall the 32 bit runtime (SAP Crystal Reports runtime engine for .NET Framework 4 (32-bit)).  That shouldn't be needed on a 64 bit machine.

What support pack level do you have installed?

http://scn.sap.com/docs/DOC-7824