Really hope we'll hear more about .net native soon, especially for non store apps.
We've heard that both asp.net5 and .net native will run .net core, and we're able to write "asp.net 5 console apps" that hanselman said at some point is actually ".net core" console apps. so it's reasonable to infer that console apps could also be compiled with .net native
This is super interesting from an native interop perspective, in perticular for games and as a kind of replacement for managed directx programming. another huge thing would be as a replacement for the microframework. this is also sometihng that's been alluded to but i really hope we can get some hard info on that soon.