I think this partly depends on the Gfx Card but...
if your Gfx card has svideo see if the display control panel lets you pick "extend display"
then in your app use the windows API calls that will capture input.
you can force the mouse and keybaord input focus to your app.
just make a form with no borders and the size of the screen.
for some info on how to make full-screen look at the starter kit for making a screen saver -- it has some code in that you may want to steal
