Reading the [
Symantec technical description], it looks like you not only have to remove the appendage(s), but will also need to correct the PE file's header. Their removal instructions suggest that they don't even attempt to undo this, instead choosing to delete the files.
Given that Windows does have "File Protection" this may or may not work. If you've got a backup, then try it.
I'd probably use System File Checker, once I was certain that the pox wasn't running. Though you'd have to check that the SFC.EXE file wasn't infected, beforehand.
eg Start, Run:
SFC /scannow