I've helped a lot of people set it up on IIS6 and IIS7.
Run it in Classic mode if you use IIS7.
One of the more well know people using it is Dave Burke:
http://dbvt.com/blog/post/2008/06/BlogEngineNet-and-Me.aspxby the way, if you're looking for an IIS7 host...
Look here for 6 free months:
http://blogcastrepository.com/blogs/wisemx/archive/2008/05/27/using-detailed-errors-in-iis-7-0.aspxNote: That's not an advertisement, simply a honest offer to ASP.NET developers