Actually, AndyC just about hit the nail on the head, it has turned out to be a missing DLL on 2 seperate occasions, prompting vista to declare the app not working, and shut it down.
It may be because the app is in debug config at the moment with no 'overall' exception handling procedure.
Maybe also that I never shipped the pdb file, so it might actually be that causing the message, but either way vista is definitely messing up my debugging!