Protein contact prediction from amino acid co-evolution using convolutional networks for graph-valued images
Download this episode
Proteins are the "building blocks of life", the most abundant organic molecules, and the central focus of most areas of biomedicine. Protein structure is strongly related to protein function, thus structure prediction is a crucial task on the way to solve many biological questions. A contact map is a compact representation of the three-dimensional structure of a protein via the pairwise contacts between the amino acid constituting the protein. We use a convolutional network to calculate protein contact maps from inferred statistical coupling between positions in the protein sequence. The input to the network has an image-like structure amenable to convolutions, but every "pixel" instead of color channels contains a bipartite undirected edge-weighted graph. We propose several methods for treating such "graph-valued images" in a convolutional network. The proposed method outperforms state-of-the-art methods by a large margin. It also allows for a great flexibility with regard to the input data, which makes it useful for studying a wide range of problems.
Available formats for this video:
Actual format may change based on video formats available and browser capability.
Comments have been closed since this content was published more than 30 days ago, but if you'd like to send us feedback you can Contact Us.