e5 Workflow is an adaptive case management platform that optimizes and automates back-office processes to improve productivity and quality while reducing cycle time. It is an Enterprise application that deeply leverages the Microsoft stack, particularly SQL 2012, .Net 4.0, Office 365 and SharePoint 2010 to deliver a highly adaptive and scalable solution. It is a market leader in the Australian Health and Financial services sectors and has recently opened an office in the USA following successes in that market. Traditionally deployed on premise or via privately hosted cloud, the Windows Azure IaaS offering provides the ideal platform on which to leverage the cloud to maximise the opportunity to deliver the power of e5 process management as a Service . In this session we share our experience in porting real-world e5 deployments to Azure VM Roles including the integration and security challenges of hybrid deployments.