From our ongoing dialog with our customers we've learned that they are eager to understand the dynamics of the malware ecosystem and antimalware solutions. The evolving malware industry poses great challenges for antimalware researchers to keep pace with attackers' methods in order to stay ahead of them. This presentation highlights key findings on malicious software and potentially unwanted software as well as some important case studies. It shares the advanced malware protection research and technologies of Microsoft Malware Protection Center (MMPC), the endpoint, the back end, the cloud-based components and infrastructure that address the scalability and complexity of the malware ecosystem, and underscores the importance of timely protection. It presents the data-driven protection story of Microsoft antimalware solutions by deep diving into key areas such as on-demand, real-time protection, unknown threats, performance, cloud security, heuristic detections, signature updates and deployment processes, false positive prevention and resolution, and web security, and it explains how these key areas connect to the underlying advanced technologies to showcase the strengths of Microsoft Forefront.