It makes my eyes water within a few minutes so a perfectly good browser, one that I've always used over the other ones, has become unusable to me in the latest version because they refuse to let me choose to use it the way I want to.
There aren't affordable Retina displays yet for the PC, so scratch the second excuse. Years from now it will be viable to get rid of it, but certainly not now. It doesn't help matters that Windows DPI scaling is all but useless.
Agreed, the font rendering is awful. I like IE10's speed but no way am I using it with that atrocious rendering (1080p at 23").