What about a new XBox?

XBox Mobile (Sony Vita)?

This would be insanely cool, a mobile phone capable of playing current XBox games.

HD Kinect? Enough for precision Finger joint recognition and facial expression recognition

Imagine a shoot-em-up where your guns are your hands.

For accessibility imagine someone using Skype where their signing is automatic "translated" into text / speech. And the other callers speech is translate into text / signing.