A high level synopsis of Microsoft's Technical Computing offerings is presented by Ryan Waite, General Manager for High Performance Computing. The sheer size of generated data is a key driver in today's computational ecosphere. By the end of 2010, over 1.2 zetabyte of data will have been generated. Microsoft has been working closely with Intel to integrate their Parallel Studio product into Visual Studio 2010. R2 is Microsoft's third release of the HPC product built on Windows, scalable to thousands of nodes. This release realizes the product team's vision of democratizing high performance computing, simplifying ease-of-use by means of intuitive interfaces such as Excel 2010, while meeting the performance needs of the HPC community. The distributed memory and resource model is implemented in Microsoft's cloud computing solution, with automated service management, relational storage, and information management suites available on the Windows Azure platform. From client, to cluster, to cloud, our customers' computational challenges are covered.